Science & Health
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COVID-19 Makes Science Harder as Britain Battles Over Best Strategy

Some top scientists in Britain are calling on Prime Minister Boris Johnson’s ruling Conservative government to shift strategy on the coronavirus pandemic and adopt a “herd immunity” approach, allowing people who are less likely to become seriously ill from the virus to return to normal life. “The most compassionate approach that balances the risks and benefits of reaching herd immunity is to allow those who are at minimal risk of death to live their lives normally to build up immunity to coronavirus through natural infection, while better protecting those who are at highest risk. We call this focused protection,” the scientists said in a petition known as the Great Barrington Declaration. A man sells face masks, following the outbreak of the coronavirus disease, on a street in Manchester, Britain, Oct. 7, 2020.The intervention by scientists from several universities, including the universities of Oxford and Cambridge, comes as surging coronavirus infection rates have put Britain on the brink of tougher lockdown measures. The government’s scientific advisers are calling for “urgent and drastic action.” Infection rates have doubled in the past 11 days. On Tuesday, Britain recorded 14,542 new confirmed cases. Hot spots are popping up across the country, although most are concentrated in the north, where 16 million people are already under partial lockdown.  The authors and co-signers of the Great Barrington Declaration, named after the Massachusetts town in the United States where it was first drafted and signed in 2020, argue that pandemic lockdowns are having “devastating effects” on public health by upending routine health care and harming mental health.  They warn that tighter restrictions and lockdowns will lead to greater mortality. Professors Martin Kulldorff of Harvard University, Sunetra Gupta of Oxford University and Jay Bhattacharya of Stanford University drafted the declaration.  Many of Britain’s scientific advisers say a herd immunity strategy would be “grotesque” and amount to writing off sick and disabled people. Other critics say it was the approach the Johnson government tried earlier this year, and that it led to more deaths than necessary. Herd immunity The theory of herd immunity is based on the idea that once about 60% of the population has been infected, it becomes immune from further reinfection. That, in turn, provides some protection to those who are not immune because the virus will spread much more slowly or may just disappear. Most of the government’s advisers dismiss herd immunity as a viable strategy, arguing that immunity is only short-term. A person is tested for COVID-19 at a drive-through testing center in a car park in Chessington, Greater London, Oct. 7, 2020.Rupert Beale, a clinician scientist group leader at the London-based Francis Crick Institute, said herd immunity is unlikely to kick in before vaccines are ready. He also maintained that it is impossible to know who is likely to become seriously ill from the virus. Many government advisers are now urging a national lockdown aimed at lowering the infection rate and avoiding hospitals becoming overwhelmed with the sick. Professor Calum Semple of the University of Liverpool and a member of the government’s main scientific advisory group on the pandemic, told the BBC on Wednesday that a “circuit-breaker” national lockdown was long overdue.  Another government adviser, Professor John Edmunds of the London School of Hygiene & Tropical Medicine, said Wednesday that localized measures are failing, and much more stringent lockdown restrictions are needed. “These local restrictions that have been put in place in much of the north of England really haven’t been very effective,” he said. Impact of lockdowns The infighting among scientists comes as mayors of towns in the north of England have started to question the orthodoxy of lockdowns, fearing that tighter and prolonged shutdowns are causing irreparable damage to their local economies, as well as having a long-term impact on mental health.  Local leaders say they are better placed to know when and how to tighten restrictions, or whether they are needed at all. They fear central governments are not getting the right balance between protecting lives and saving livelihoods and businesses. Andreas Spahiu, owner and manager of Don Vito’s restaurant, is seen inside his premise, which is closing at the weekend due to the coronavirus restrictions, in Newcastle upon Tyne, Britain, Oct. 7, 2020.The signatories of the declaration also argue that lockdowns are having a series of negative impacts. They point to lower childhood vaccination rates, worsening cardiovascular disease outcomes and fewer cancer screenings that they say are affecting working-class people and young people the most. Hospital admissions in England jumped by a quarter in one day this week, and worries are mounting about the ability of the National Health Service to cope as winter sets in. The government’s testing system is also straining to cope with people wanting tests and complaining that they are unable to get them. Further delays are likely, as it emerged this week that there are supply shortages from the diagnostics company Roche because of logjams in the supply chains of swabs, screening kits and reagents, the chemicals needed for the tests. The infighting among scientists is also being mirrored among Johnson’s cabinet ministers. Liz Truss, secretary of state for international trade, is publicly arguing against further lockdown measures, saying it would “set us back hugely.” 
 

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Economy & business/Silicon Valley & Technology
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Google, Oracle Meet in Copyright Clash at Supreme Court

Tech giants Google and Oracle are clashing at the Supreme Court in a copyright dispute that’s worth billions and important to the future of software development.
The case before the justices Wednesday has to do with Google’s creation of the Android operating system now used on the vast majority of smartphones worldwide. Google says that to create Android, which was released in 2007, it wrote millions of lines of new computer code. But it also used 11,330 lines of code and an organization that’s part of Oracle’s Java platform.
 
Google has defended its actions, saying what it did is long-settled, common practice in the industry, a practice that has been good for technical progress. But Oracle says Google “committed an egregious act of plagiarism” and sued, seeking more than $8 billion.
The case has been going on for a decade. Google won the first round when a trial court rejected Oracle’s copyright claim, but that ruling was overturned on appeal. A jury then sided with Google, calling its copying “fair use,” but an appeals court disagreed.
Because of the death of Justice Ruth Bader Ginsburg, only eight justices are hearing the case, and they’re doing so by phone because of the coronavirus pandemic. The questions for the court are whether the 1976 Copyright Act protects what Google copied, and, even if it does, whether what Google did is still permitted.  
Oracle, for its part, says the case is simple.  
“This case is about theft,” Oracle’s chief Washington lobbyist, Ken Glueck, said in a telephone interview ahead of argument. He compared what Google did to plagiarizing from someone else’s speech. When you plagiarize one line from a speech, he said: “That’s a plagiarized speech. Nobody says, ‘Oh, well, it was just one line.'”
But Google’s Kent Walker, the company’s chief legal officer, said in an interview that Google wrote “every line of code we possibly could ourselves.”
“No one’s ever claimed copyright over software interfaces, but that’s what Oracle is claiming now,” Walker said.
Microsoft, IBM and major internet and tech industry lobbying groups have weighed in — in favor of Google.
The Trump administration, the Motion Picture Association and the Recording Industry Association of America are among those supporting Oracle.

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Science & Health
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Zimbabwe Teachers Refuse to Return to Schools Over Pay, Sanitation

Zimbabwe, like other African countries, is trying a phased re-opening of schools after closing in March due to COVID-19.But many teachers like 33-year-old Munyaradzi Masiyiwa are refusing to return to class, pointing to low pay and unsafe conditions.Masiyiwa said he makes more money selling brooms than teaching at Cranborne Boys Government High School in Harare.Sorry, but your browser cannot support embedded video of this type, you can
Paul Mavima, Zimbabwe public service minister  (Harare, October 6, 2020) says teacher salaries, about $100 a month, including a $75 “COVID-19 allowance” is all it can afford at the moment. (Columbus Mavhunga/ VOA)Public Service Minister Paul Mavima said teacher salaries, about $100 a month, including a $75 “COVID-19 allowance” is all the government can afford.”It is in this context that we are saying to civil servants please be realistic, exercise moderation in the manner in which you demand salary increases, we don’t want salary increases that will upset the stability that we have so far realized and further torpedo the economic recovery that we have started to see,” Mavima said.Without teachers in class, Zimbabwe’s school children are the ones left paying the price.Filda Rusheje, a parent of student, in Harare (October 7, 2020) wishes if the government can negotiate with the teachers on strike so that children can learn ahead of examinations. (Columbus Mavhunga/VOA)At Glen View High School, students said they only discuss lessons among themselves. Filda Rusheje is one of their parents. She is worried the children won’t learn enough to pass their exams.“The situation at schools is a tough one,” Rusheje said. “They are going to school but they are not learning. My daughter said they are just discussions among learners. They are not even sure if it’s making sense because teachers are not coming. I just wish if the government can negotiate with the teachers so that our children can learn. I want them to look after us in future.”Zimbabwe’s government has threatened to replace defiant teachers like Masiyiwa if they don’t soon return to the classrooms. 

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Arts & Entertainment/Economy & business
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Somalia Opens First Independent Modern Arts Institution

Somalia in September saw the opening of what is being touted as the country’s first independent, modern arts institution. The Somali Arts Foundation says it seeks to promote creativity and critical discussions on what it means to be a Somali. Mohamed Sheikh Nor reports from Mogadishu.  
Camera: Mohamed Sheikh Nor   Produced by: Rod James 
 

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Arts & Entertainment/Economy & business
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College Admissions Scandal Dad Sentenced to Homestay

A former tech executive was sentenced Monday to one year of home confinement for paying $300,000 to bribe his son’s way into Georgetown University as a tennis recruit, even though the son did not play tennis.
Peter Dameris, of Pacific Palisades, California, appeared before a Boston federal court judge via video because of the coronavirus pandemic. He pleaded guilty in June to one count of conspiracy to commit mail fraud and honest services mail fraud.  
His sentence also included a $95,000 fine and three years of supervised release.
Prosecutors had recommended a sentence of 21 months of home confinement along with a fine of $95,000. Dameris’ lawyers asked for probation only, saying he deserved leniency to help care for a son who has leukemia.  
U.S. District Judge Richard Stearns said he took the medical considerations into account in the sentence, along with an “outpouring” of support from friends and family members who submitted letters to the court.
“I really feel for your family, and I understand your anguish,” Stearns told Dameris. “You have lived a good life, and I believe you deserve some reward for that.”
Speaking through tears, Dameris said he regrets his involvement in the scheme and takes full responsibility.
“I am enormously remorseful for the actions that have brought me before you today,” Dameris said. “My life’s sentence is, I am burdened with the memories of what I’ve done that has hurt my family and others.”
Dameris, the former CEO of technology services company ASGN Inc., joins dozens of parents and college coaches who have pleaded guilty in a sweeping nationwide college admissions scandal.
Prosecutors say Dameris agreed in 2015 to funnel the money through a sham charity set up by Rick Singer, the alleged ringleader of the scheme. Singer steered roughly half of the money to Georgetown’s former tennis coach, Gordon Ernst, who helped get Dameris’ son accepted as a tennis recruit, prosecutors say.
In court filings, Dameris apologized for influencing the admissions system but said he believed the money was going to Georgetown’s athletic programs. Prosecutors say there’s no evidence Dameris knew of any personal bribes to Ernst.
Singer pleaded guilty and is cooperating with the government’s investigation into what authorities have dubbed Operation Varsity Blues, a series of indictments that have rocked the worlds of higher education, sports and entertainment.
Ernst, who is accused of accepting $2.7 million in bribes, has pleaded not guilty. He resigned from Georgetown in 2018.
Dameris acknowledged that he later considered the scheme for his other son but did not follow through with it. Neither son was involved, and his son at Georgetown was allowed to stay and graduate.
More than 50 parents, coaches and others have been charged since investigators revealed the scheme last year. The parents paid hefty bribes to get their children into top universities with bogus test scores or fake athletic credentials, authorities say.
Prosecutors have pushed for prison time for most parents accused in the scheme, but they said home confinement was warranted in Dameris’ case because of his “unusual and compelling personal circumstances.”  
Others who have pleaded guilty include “Full House” actress Lori Loughlin and her fashion designer husband, Mossimo Giannulli. Loughlin was sentenced to two months in prison as part of plea a deal, and Giannulli was ordered to five months. The couple admitted to paying half a million dollars in bribes to get their two daughters into the University of Southern California as rowing recruits.
“Desperate Housewives” actress Felicity Huffman, also pleaded guilty for paying $15,000 to have someone rig her daughter’s college entrance exam. Huffman was sentenced to two weeks in prison.

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Science & Health
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Scientists Win Chemistry Nobel Prize for Gene Editing Development 

Two scientists have won this year’s Nobel Prize in chemistry for developing a method of gene editing. The Royal Swedish Academy of Sciences jointly awarded the $1.1 million prize to Emmanuelle Charpentier of France and Jennifer Doudna of the United States. The academy recognized their work on a tool called the CRISP/Cas9 genetic scissors, which allows scientists to cut a string of DNA at a precise position and edit genomes of animals, plants and microorganisms. Applications for the tool include plant breeding and contributing to cancer therapies. The academy said the work of Charpentier and Doudna has “revolutionized the life sciences.” The Nobel Prize in literature will be awarded Thursday, followed by the Nobel Peace Prize on Friday. Three scientists won the physics prize Wednesday for their discoveries related to black holes. Three scientists also shared the medicine prize for the discovery of Hepatitis C. 

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Science & Health
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Rapid COVID-19 Tests Offer New Tools To Slow Pandemic

As the COVID-19 pandemic marches on, new, rapid tests offer hope for pumping the brakes on the virus’ spread.  The United States is falling far short in its testing efforts. More than 4 million tests per day would be needed to control the spread of the coronavirus, according to an analysis by Brown University and A healthcare professional adds the extraction reagent and a patient specimen to Abbott’s BinaxNOW COVID-19 Ag rapid test card, Sep. 2020.The right test for the job Experts say that the best test depends on the testing strategy.   “I think there’s definitely a time and a place for all of these tests, as long as they’re used properly,” said Wyllie. Currently, the CDC only recommends COVID-19 testing if people have symptoms or if they’ve been in close contact with an infected person. Because PCR picks up even tiny quantities of the virus it is much more sensitive than antigen testing. This means that PCR can more accurately diagnose COVID-19, particularly as the disease progresses and virus levels wane. “PCR is extremely sensitive. It can detect one molecule [of the virus],” said Michael Mina, epidemiology professor at Harvard University at a press conference. “I want to make it clear that PCR is a terrific tool. If I’m a diagnostic physician, I want to use PCR.”   However, because PCR tests are so sensitive, they may give a positive result when people are no longer contagious. “We’re actually missing people during the peak of their infection and we’re catching them too late,” said Mina.   Some experts say the best approach to tackling COVID-19 is frequent, widespread testing of asymptomatic people. Less-sensitive antigen tests may do the job because they perform well when virus levels are high and detect people when they’re most infectious. Best of all, these tests are cheap and quick. “If my goal is to use testing as a way to remove people who are infectious from the population, that’s where these rapid antigen tests really start to shine,” said Mina. According to Mina, the recent granting of an Emergency Use Authorization to a rapid antigen test is a step in the right direction. This type of simple, paper test could one day be available for use in homes. Although the FDA has not yet approved a home COVID-19 test, it recently provided recommendations for home testing standards, stating that these tests will be a “game changer in our fight against COVID-19.” “I really like the idea of a rapid test that you can do at home,” said Yale’s Wyllie. “This idea that we can get up in the morning and as we’re getting ready for work or whatever, taking a test.” But Wyllie says the success of this approach depends on test sensitivity and how often testing is done. “The problem with antigen tests at the moment is that I just don’t think they’re sensitive enough sometimes.”   Even with daily testing, a low sensitivity test could fail to identify the virus before a person becomes infectious. “In that 24 hours, they could go to a wedding, they could go to a funeral, they could go to a church choir. All these settings that we’re seeing become superspreading events.”How Superspreaders – People and Places – Drive the COVID-19 Pandemic A mix of biology, behavior and location is found to produce a majority of cases The limits of testing Experts agree that no test is perfect. Results depend on many factors such as the type of test, how the sample was collected and when the test was taken. “A negative [diagnostic] test doesn’t exclude the possibility that you will test positive tomorrow if you’re within that 14-day incubation period,” said UNC’s Weber. “I think testing is an important strategy but it’s not a substitute for physical distancing and mask wearing.” Steve Baragona contributed to this report.

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