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FDA Gives Emergency Authorization for Pfizer COVID Pill

The U.S. Food and Drug Administration authorized the emergency use of an antiviral COVID-19 pill, the pill’s maker Pfizer Inc. said Wednesday.

The company says the pill, which is to be taken with another antiviral drug, ritonavir, is 90% effective in preventing hospitalization and death in high-risk people.

“The efficacy is high, the side effects are low and it’s oral. It checks all the boxes,” Dr. Gregory Poland of the Mayo Clinic told The Associated Press. “You’re looking at a 90% decreased risk of hospitalization and death in a high-risk group—that’s stunning.”

The pill is the first at-home treatment for the virus and is approved for use in those 12 and older who are at high risk.

Pfizer says it’s ready to start delivery of the drug immediately in the U.S. and will produce 120 million courses in 2022.

The U.S. government has a contract with the company for 10 million courses priced at $530 per course.

The drug will be sold under the name Paxlovid and will have to be taken every 12 hours for five days once COVID-19 symptoms appear. Potential users of the new drug will have to show a positive virus test.

Drug giant Merck is also working on a similar drug.

Despite the promise, health officials say getting a vaccine is still the best way to stave off the worst effects of the virus. 

Some information in this report comes from The Associated Press and Reuters.

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India Could Raise Marriage Age for Women from 18 to 21

In India, the government has proposed legislation to raise the minimum age of marriage for women from 18 to 21 years old, bringing it on par with men and saying it will empower women. But many women activists say the planned law would do little to address deep-seated societal problems that result in millions of young girls being married at an age even younger than 18.

“We are doing this so that they can have time to study and progress. The country is taking this decision for its daughters,” Prime Minister Narendra Modi said after The Prohibition of Child Marriage [Amendment] Bill was introduced in parliament Tuesday. The action comes more than a year after he said, during an Independence Day speech, that the government is considering raising the legal age of marriage for women.

The government says the aim is to provide equal opportunity to women by giving them more time to complete their education, access employment opportunities, attain psychological maturity before marriage and ensure gender parity.

“In a democracy, we are 75 years late in providing equal rights to men and women to enter into matrimony,” Smriti Irani, minister of women and child development, said in parliament Tuesday.

The proposed law would mark a major change for women in a country where, according to several estimates, about 50 percent marry before turning 21.

Some women’s groups have supported the bill. “Completing her education and employability ensures a better life for a girl than being dependent on her husband all her life,” Ranjana Kumari, director of the New Delhi-based Center for Social Research, told VOA.

She wants the marriage age for both genders to be the same. “Why should the boy be elder to the girl? Who has made that decision?” she questioned.

The government says the proposed change is also prompted by concerns for the health of women who become mothers at a young age. Early marriages are linked to higher infant mortality and low life expectancy, especially among rural women.

According to Irani, raising the age of marriage for women would help bring down the incidence of teenage pregnancies.

Some experts, however, cautioned that the proposal might backfire because it does not address the underlying causes of early marriage such as poverty, patriarchal attitudes and lack of access to education, and fear that if these root causes are not solved, an age change could do more harm than good.

They point out that although marriages for girls under 18 are currently illegal, child marriages still pose a major challenge in the country — as many as one quarter of women ages 20 to 24 were married before they turned 18, according to the National Family Health Survey, 2019-21.

“The bill is well-intentioned but thoughtless,” says Mary John, professor at the Center for Women’s Development Studies, a research and advocacy organization. According to her, many of the indicators that the government is trying to address, like maternal mortality, will not be solved by simply raising the age of marriage.

“An anemic woman will remain anemic, whether she gets married at 18 or 21. She stops being anemic only if she gets better health and nutrition,” John told VOA.

Pointing out that the proposed law will lead to criminalizing many women whose families marry them off at an early age, she said, “It betrays a carelessness and disinterest in women’s empowerment and will leave a large number of women without protection.”

Some women activists call the bill a token gesture that will not empower women. They say that the government should focus on improving access to educational facilities, which remain deficient, especially in the country’s vast rural areas, better nutrition and health care, and ensure safety and security for women.

“There cannot be any gain through a law either educationally or economically or on health indicators. Unless you earmark enough funds to tackle these basic problems, how can you change these issues?” Annie Raja, general secretary of The National Federation of Indian Women, told VOA.

She says if the aim is to implement gender parity, then the government should reduce the marriage age for men to 18.

Others argue that if a girl at 18 is old enough to vote or be treated as an adult if she commits a crime, there is no reason why she cannot marry at that age.  

 

Responding to such criticism, supporters of the bill say that this move should not be seen as a problem but an opportunity. “There are a lot of other recommendations made by the government to facilitate education for girls up to graduation and also to have reproductive health rights made available to all girls,” according to Kumari.

However, she agrees that every arm of society, such as government, political parties or civil society, will have to work to make a higher age for marrying girls acceptable to communities. “Just by changing the law you do not change society or the institution of marriage, which is a social institution accompanied by cultural practices.”

The proposal has also been welcomed by hundreds of young girls, who have been campaigning in the northern Indian state of Haryana to raise the marriage age for women.

“It’s a huge step forward,” said 17-year-old Prachi Chauhan, one of the campaigners. “Such a law will help take away societal and parental pressure to get married soon after turning 18 that many girls face.”

Suhasini Sood contributed to this story.

 

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Australian Research Identifies Kidney-Protecting Gene

Researchers in Australia have identified a gene that indicates the kidney has its own way of resisting damage. However, they have also identified a mutation of the gene that can in patients with, for example, diabetes, trigger the development of renal disease. 

A gene called VANGL1 has been found to help stop the immune system from attacking the kidney. But Australian researchers say the genetic mutation, which is present in about 15% of the population worldwide, can cause renal disease in patients with diabetes and other autoimmune conditions.   

The mutation is highly prevalent among indigenous people on the Tiwi Islands, 80 kilometers from the city of Darwin in the Northern Territory. According to the study, just less than 50% of the islands’ residents have the genetic mutation.   

The islands’ recorded rates of kidney disease are four times those of mainland indigenous Australians and about 11 times that of non-Indigenous Australians, according to researchers. 

Dr. Simon Jiang is from the John Curtin School of Medical Research at Australian National University. He says the mutation is mostly benign in healthy adults. 

“If your body is not inflamed and you are otherwise healthy, it is probably not too much of an issue. It is when you have another condition that occurs on top of it. And so in the Tiwi Islands, rates of infection, of diabetes and probably some immune diseases, are a lot higher than the rest of Australia. And so, when you have that process happening within your body, what is initially a reasonably benign mutation suddenly takes on a new turn and becomes something that is really bad news for the kidney,” Jiang said.  

The study could lead to better transplant screening that would identify potential donors who have the genetic mutation. 

The study was published Wednesday in the journal Cell Reports Medicine. 

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NHL Players Will Not Compete at Beijing Olympics: Reports 

National Hockey League players will not compete in February’s Beijing Winter Olympics in the wake of 50 NHL games being postponed over COVID-19 issues, according to multiple reports Tuesday. 

ESPN, The New York Times, The Washington Post, USA Today and other newspapers cited unnamed sources in saying the league and the NHL Players Association had reached agreement not to send talent to China. 

Without the NHL’s elite millionaire stars, national teams at the Olympics will likely resemble those at the 2018 Pyeongchang Winter Games, when minor-league and recently retired players filled out rosters, with the Olympic Athletes from Russia capturing the gold medal. 

The NHL and players union had agreed to send players to the 2022 and 2026 Winter Olympics unless league seasons were impacted by COVID-19 postponements. 

With Tuesday’s Washington at Philadelphia game being postponed by an outbreak from the visitors, the NHL has been forced to postpone 50 games this season.

Staying home during the period of the Beijing Olympics would open two weeks to reschedule contests and still provide something of a rest for most of the players. 

The NHL plans to pause the season after Tuesday’s lone contest, which finds Tampa Bay at Vegas. 

Games planned for Wednesday and Thursday were called off ahead of a scheduled three-day Christmas weekend break, which was tweaked to have players return to work on Sunday. 

Teams would be off Wednesday through Saturday and return Sunday for testing, with negative tests required to enter team facilities. 

On Sunday, the NHL announced that all games involving cross-border travel for US and Canadian clubs would not be played. Nine teams had already shut down operations to the break by Monday. 

That’s when concerns rose about the NHL skipping Beijing. 

“The NHL and NHLPA are actively discussing the matter of NHL Player participation in the 2022 Winter Olympics in Beijing, China, and expect to be in a position to announce a final determination in the coming days,” a league spokesman said Sunday. 

 

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Mormon Billionaire Leaves Faith, Rebukes LGBTQ Rights Stance

An advertising-technology billionaire has formally resigned his membership in The Church of Jesus Christ of Latter-day Saints and rebuked the faith over social issues and LGBTQ rights in an unusual public move. 

Jeff T. Green has pledged to donate 90% of his estimated $5 billion advertising-technology wealth, starting with a donation to a LGBTQ-rights group in the state, the Salt Lake Tribune reported.

In an unusual public step, Green said in a Monday resignation letter to church President Russell M. Nelson that he hasn’t been active in the faith widely known as Mormon for more than a decade but wanted to make his departure official and remove his name from membership records. 

“I believe the Mormon church has hindered global progress in women’s rights, civil rights and racial equality, and LGBTQ+ rights,” he wrote. Eleven family members and a friend formally resigned along with him. He will donate $600,000 to the group Equality Utah.

The church didn’t immediately return a message from The Associated Press seeking comment Tuesday, but in recent years has shown a willingness to engage on LGBTQ rights that is unusual for a conservative faith. While it maintains its opposition to same-sex marriage, the faith didn’t block a 2019 ban on so-called conversion therapy in Utah and in November high-ranking leader Dallin Oaks said in a speech that religious rights and LGBTQ rights can coexist. 

Green, for his part, said most church members “are good people trying to do right,” but he also worries about the faith’s transparency around its history and finances.

Green, 44, now lives in Southern California. He is the CEO and chairman of The Trade Desk, an advertising technology firm he founded in 2009.

He also mentioned concerns about a $100 billion investment portfolio held by the faith. It was the subject of an Internal Revenue Service whistleblower complaint in 2019, from a former employee who charged the church had improperly built it up using member donations that are supposed to go to charitable causes.

Leaders have defended how the church uses and invests member donations, saying most is used for operational and humanitarian needs, but a portion is safeguarded to build a reserve for the future. The faith annually spends about $1 billion on humanitarian and welfare aid, leaders have said. 

The church has also come under criticism for conservative social positions. Women do not hold the priesthood in the faith, and Black men could not until the 1970s.

In recent years, though, the faith has worked with the NAACP and donated nearly $10 million for initiatives to help Black Americans. It has also worked with Equality Utah to pass a state LGBTQ nondiscrimination law, with religious exemptions.

Another prominent onetime Latter-day Saint sued the faith this year, accusing it of fraud and seeking to recover millions of dollars in contributions. James Huntsman is a member of one of Utah’s most prominent families and brother of a former governor. The suit was later tossed out. 

 

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